Without aįluorescent label, it can be difficult to determine the tethering of these biomolecules to In bio-nanotechnology, nanoparticles are used as vehicles for nanomedicine, 1,2 visual aids in point-of-care diagnostics, 3–6 markers inĪpplications, the biomolecules that are conjugated onto nanoparticles can varyĭramatically in size, with Stokes radii as small as 7 Å and as large asĬorresponding molecular weights ranging from 300 000 Da. Including colloid sizing, particle corona characterization, protein footprinting, and With these capabilities, PSD can reliably aid in a wide variety of applications, Furthermore, PSD is sensitive enough to detect biomolecular surface modifications of Less sample volume than current standard techniques and use PSD to quantify particle We demonstrate the rapid sizing of particles using three orders-of-magnitude In particle size and distribution as a function of small, label-free, surface modifications of Principles of particle image velocimetry to measure the diffusivity of particlesĬoefficient of particles as small as 30 nm in diameter and is used to characterize changes Scattering Diffusometry (PSD), a method that utilizes dark field microscopy and the
Physiochemical characterization of colloidal particles will become increasingly important. As the field of colloidal science continues to expand, tools for rapid and accurate